Clindamycin Impurity 158 CAS 887402-22-4 (free base)
| CAS No. | 887402-22-4 (free base) |
| Molecular Formula | C18H33ClN2O7S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Clindamycin Impurity 158 (CAS 887402-22-4 (free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C18H33ClN2O7SHCl and a molecular weight of 493.44 g/mol.
Clindamycin Impurity 158 (C18H33ClN2O7SHCl) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C18H33ClN2O7S HCl |
| Molecular Weight | 493.44 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Clindamycin Standards
- Clindamycin Impurity 164 (CAS 1123211-65-3 (free base))
- Clindamycin Impurity 16 (CAS 1123211-66-4)
- Clindamycin Impurity 73 (CAS 1123211-66-4 (free base))
- Clindamycin Pentadecanoate HCl (CAS 1123211-67-5 (free base);)
- Clindamycin Heptadecanoate (CAS 1123211-69-7 (free base))
- Clindamycin Impurity 22 HCI (CAS 1123211-70-0（free base）)
- Clindamycin phosphate ester EP impurity F isomer (CAS 1149764-21-5)
- Clindamycin Phosphate Sulfoxide Impurity (CAS 1228573-90-7)
Recommended Standards
- Lumateperone Impurity 52 (CAS CATO-C4X-220152)
- Posaconazole Impurity 164 (CAS CATO-C4X-1208164)
- Rebamipide Impurity 54 (CAS CATO-C4X-152354)
- 3-((2,4-Difluorobenzyl)oxy)benzaldehyde (CAS 1270984-72-9)
- 2-[(2-Thienylcarbonyl)amino]-1,3-oxazole-4-carboxylic acid (CAS 1204297-76-6)
- 1-Oxopropan-2-yl acetate (CAS 22094-23-1)
- 20(R), 22(R)-Dihydroxy Cholesterol (CAS 596-94-1)
- 3-((Benzyloxy)methyl)cyclobutanecarboxylic acid (CAS 1363381-57-0)
- 2-(2-Chlorophenyl)-1,3-thiazole-5-carboxylic acid (CAS 1018520-26-7)
- (Leu31,Pro34)-Peptide YY (human) trifluoroacetate salt (CAS 179986-95-9)
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